ʻenehana hoʻoneʻe wela hoʻoheheʻe

ʻO nā pyrogens, i ʻike ʻia hoʻi he endotoxins, ua hana ʻia i loko o ka pā extracellular o Gram-negative bacteria, ʻo ia hoʻi, nā ʻāpana o nā kupapaʻu bacteria.He mea lipopolysaccharide ia me ka nui molekala pili mai kekahi mau tausani a hiki i mau haneli tausani, ma muli o ke ʻano o ka bacteria e hana mai ai.I loko o ka hoʻonā wai, hiki ke ʻokoʻa ka nui o ka molekala pili mai nā haneli kaukani a i nā miliona
Inā hui pū ʻia kahi ʻāpana o ka pyrogen i loko o ka lāʻau lapaʻau a hoʻokomo ʻia i loko o ka ʻōnaehana koko o ke kanaka, e hōʻeha ia i ke kuni nui a me ka make.No laila, he mea pono e hoʻemi i ka nui o ka pyrogen i loko o ka wai lāʻau lapaʻau e like me ka mea hiki, ʻoiai ke ʻoi aku ka nui o ka injection (e like me ka infusion nui), ʻoi aku ka paʻakikī o ka koi ʻana o ka pyrogen.

ʻO ka Depyrogenation o ka wai hoʻoheheʻe (a i ʻole ka wai no ka injection) kahi loulou hana kumu ma ka ʻoihana lāʻau lapaʻau e hoʻokō ai i nā lula hoʻāʻo o ka Pharmacopoeia.I kēia manawa, hoʻokomo pinepine ʻia nā ʻano no ka depyrogenation i nā ʻano 3 aʻe:

1. Hoʻopuka ke ʻano distillation i ka wai depyrogenated, i hoʻohana ʻia e like me ka wai no ka injection, ka wai holoi, a me nā mea ʻē aʻe, akā kiʻekiʻe kona kumukūʻai.
2. Depyrogenation ma ke ala adsorption.ʻO kekahi o nā ala ʻo ia ka adsorbent surface adsorbent i nā mea pyrogenic a hiki i nā mea huahana ke hele i loko.ʻO ke ala ʻelua, ʻo ka adsorbent adsorbent ka mea huahana a hiki i ka pyrogen ke kahe i waho.
3. ʻO keʻano o ka hoʻokaʻawaleʻana o ka membrane no ka weheʻana i ka pyrogen ma keʻano he kaʻina hana hou a ke kaulana a hoʻohanaʻia kaʻenehana hou i kaʻoihana lāʻau.ʻO ke kumumanaʻo o ka ultrafiltration e wehe i ka pyrogen ʻo ia ka hoʻohana ʻana i kahi membrane ultrafiltration liʻiliʻi ma mua o ke kaumaha molecular o ka pyrogen e hoʻopaʻa i ka pyrogen.Ua hōʻoia ʻia kēia ʻano hana.A loaʻa iā ia nā pōmaikaʻi o ka haʻahaʻa haʻahaʻa haʻahaʻa, kiʻekiʻe ka huahana huahana a me ka maikaʻi o ka huahana.